منابع مشابه
Myosins pull together—separately
D on’t tell your high school football coach, but it is possible to have teamwork even if nobody’s in charge. Inside a cell, for example, myosin VI motors work in concert to haul cargoes along the actin cytoskeleton, Sivaramakrishnan and Spudich reveal (1). Instead of providing muscle power, myosin VI is one of the unconventional myosins whose job is intracellular transportation. Researchers hav...
متن کاملMultiplying myosins.
M yosins are a diverse family of actin-based molecular motors that appeared early in eukaryotic evolution. Just how early, and how diverse, has begun to become clear from work that appears in this issue of PNAS (1) and recent work from Nature (2). For most of its existence, the term ‘‘myosin’’ applied only to the actinactivated ATPase that forms the bipolar thick filaments of muscle and the cyt...
متن کاملMyosins: a diverse superfamily.
Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic analysis currently places myosins into 15 classes. The conventional myosins which form filaments in muscle and non-muscle cells form class II. There has been extensive characterization of these myosins and much is known about their function. With the exception of class I and class V myosins, little is known...
متن کاملMyosins, Actin and Autophagy
Myosin motor proteins working together with the actin cytoskeleton drive a wide range of cellular processes. In this review, we focus on their roles in autophagy - the pathway the cell uses to ensure homeostasis by targeting pathogens, misfolded proteins and damaged organelles for degradation. The actin cytoskeleton regulated by a host of nucleating, anchoring and stabilizing proteins provides ...
متن کاملMyosins in cell junctions
The development of cell-cell junctions was a fundamental step in metazoan evolution, and human health depends on the formation and function of cell junctions. Although it has long been known that actin and conventional myosin have important roles in cell junctions, research has begun to reveal the specific functions of the different forms of conventional myosin. Exciting new data also reveals t...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1871if